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S modafinil has a shorter half life, and is more extensively metabolized than the R enantiomer. It normally begins during the first or second decade of life, and signs may develop quickly over a couple of weeks or months, with extreme daytime sleepiness (EDS) and cataplexy being probably the most dramatic and observable signs. Lengthy-term efficacy and security of modafinil (Provigil) for the treatment of extreme daytime sleepiness associated with narcolepsy.

14. Fava M, Thase ME, DeBattista C. A multicenter, placebo-managed research of modafinil augmentation in partial responders to selective serotonin reuptake inhibitors with persistent fatigue and sleepiness. Modafinil augmentation of SSRI therapy in patients with main depressive disorder and excessive sleepiness and fatigue: a 12-week, open-label, extension - http://www.Sharkbayte.com/keyword/extension research. 16. Konuk N, Atasoy N, Atik L, Akay O.

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